Article
[Von Willebrand disease : diagnosis and management].
Der Internist - 1 Sept 2010
Antony C, Rossaint R, Schaelte G
Abstract excerpt
Von Willebrand's disease is an inherited bleeding disorder with a prevalence as high as 1% in the general population. The disease is caused by the quantitative deficiency or dysfunction of von Willebrand factor (VWF), a large multimeric glycoprotein. VWF has two main functions in hemostasis: it is essential for platelet-plug formation as an adhesion protein and it forms a non-covalent complex with coagulation...
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