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Article

Differentiation-associated genes regulated by c-Jun and decreased in the progression of esophageal squamous cell carcinoma.

PloS one - 1 Jan 2014

Luo Aiping, Yu Xinfeng, Li Guichang, Ma Gang, Chen Hongyan, Ding Fang, Li Yi, Liu Zhihua

Abstract excerpt

Transcription factor c-Jun plays a key role in controlling epithelium cell proliferation, apoptosis and differentiation. However, molecular mechanism and biological functions of c-Jun in squamous differentiation and the progression of esophageal squamous cell carcinoma (ESCC) remain elusive. In this study, we found that c-Jun bound directly to the promoter region, and activated the transcription of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24796531
DOI: 10.1371/journal.pone.0096610
PMCID: PMC4010476

Genes

SPRR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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