Article
Whole genome prediction of bladder cancer risk with the Bayesian LASSO.
Genetic epidemiology - 1 Jul 2014
de Maturana Evangelina López, Chanok Stephen J, Picornell Antoni C, Rothman Nathaniel, Herranz Jesús, Calle M Luz, García-Closas Montserrat, Marenne Gaëlle, Brand Angela, Tardón Adonina, Carrato Alfredo, Silverman Debra T, Kogevinas Manolis, Gianola Daniel, Real Francisco X, Malats Núria
Abstract excerpt
To build a predictive model for urothelial carcinoma of the bladder (UCB) risk combining both genomic and nongenomic data, 1,127 cases and 1,090 controls from the Spanish Bladder Cancer/EPICURO study were genotyped using the HumanHap 1M SNP array. After quality control filters, genotypes from 475,290 variants were available. Nongenomic information comprised age, gender, region, and smoking status. Three Bayesian...
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