In vitro evaluation of a soluble Leishmania promastigote surface antigen as a potential vaccine candidate against human leishmaniasis.

doi:10.1371/journal.pone.0092708

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Article

In vitro evaluation of a soluble Leishmania promastigote surface antigen as a potential vaccine candidate against human leishmaniasis.

PloS one - 1 Jan 2014

Chamakh-Ayari Rym, Bras-Gonçalves Rachel, Bahi-Jaber Narges, Petitdidier Elodie, Markikou-Ouni Wafa, Aoun Karim, Moreno Javier, Carrillo Eugenia, Salotra Poonam, Kaushal Himanshu, Negi Narender Singh, Arevalo Jorge, Falconi-Agapito Francesca, Privat Angela, Cruz Maria, Pagniez Julie, Papierok Gérard-Marie, Rhouma Faten Bel Haj, Torres Pilar, Lemesre Jean-Loup, Chenik Mehdi, Meddeb-Garnaoui Amel

Abstract excerpt

PSA (Promastigote Surface Antigen) belongs to a family of membrane-bound and secreted proteins present in several Leishmania (L.) species. PSA is recognized by human Th1 cells and provides a high degree of protection in vaccinated mice. We evaluated humoral and cellular immune responses induced by a L. amazonensis PSA protein (LaPSA-38S) produced in a L. tarentolae expression system. This was done in individuals...

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PMID: 24786587
DOI: 10.1371/journal.pone.0092708
PMCID: PMC4008367

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