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High-throughput sperm differential proteomics suggests that epigenetic alterations contribute to failed assisted reproduction

29 Apr 2014

Abstract excerpt

STUDY QUESTION: Are there quantitative alterations in the proteome of normozoospermic sperm samples that are able to complete IVF but whose female partner does not achieve pregnancy? SUMMARY ANSWER: Normozoospermic sperm samples with different IVF outcomes (pregnancy versus no pregnancy) differed in the levels of at least 66 proteins. WHAT IS KNOWN ALREADY: The analysis of the proteome of sperm samples with...

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PMID: 24781426
DOI: 10.1093/humrep/deu073

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