Article
A small system--high-resolution study of metabolic adaptation in the central metabolic pathway to temperate climates in Drosophila melanogaster.
Molecular biology and evolution - 1 Aug 2014
Lavington Erik, Cogni Rodrigo, Kuczynski Caitlin, Koury Spencer, Behrman Emily L, O'Brien Katherine R, Schmidt Paul S, Eanes Walter F
Abstract excerpt
In this article, we couple the geographic variation in 127 single-nucleotide polymorphism (SNP) frequencies in genes of 46 enzymes of central metabolism with their associated cis-expression variation to predict latitudinal or climatic-driven gene expression changes in the metabolic architecture of Drosophila melanogaster. Forty-two percent of the SNPs in 65% of the genes show statistically significant clines in...
Topics
- Acclimatization
- Animals
- Drosophila Proteins
- Drosophila melanogaster
- Gene Expression Regulation
- Genetic Variation
- Glycolysis
- Mammals
- Metabolic Networks and Pathways
- Phylogeography
- Polymorphism, Single Nucleotide
- Selection, Genetic