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Article

Using VAAST to Identify Disease-Associated Variants in Next-Generation Sequencing Data.

Current protocols in human genetics - 24 Apr 2014

Kennedy Brett, Kronenberg Zev, Hu Hao, Moore Barry, Flygare Steven, Reese Martin G, Jorde Lynn B, Yandell Mark, Huff Chad

Abstract excerpt

The VAAST pipeline is specifically designed to identify disease-associated alleles in next-generation sequencing data. In the protocols presented in this paper, we outline the best practices for variant prioritization using VAAST. Examples and test data are provided for case-control, small pedigree, and large pedigree analyses. These protocols will teach users the fundamentals of VAAST, VAAST 2.0, and pVAAST...

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Identifiers

PMID: 24763993
DOI: 10.1002/0471142905.hg0614s81
PMCID: PMC4137768

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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