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Article

Metabolic profiling reveals that PNPLA3 induces widespread effects on metabolism beyond triacylglycerol remodeling in Huh-7 hepatoma cells.

American journal of physiology. Gastrointestinal and liver physiology - 1 Jul 2014

Min Hae-Ki, Sookoian Silvia, Pirola Carlos J, Cheng Jianfeng, Mirshahi Faridoddin, Sanyal Arun J

Abstract excerpt

PNPLA3 was recently associated with the susceptibility to nonalcoholic fatty liver disease, a common cause of chronic liver disease characterized by abnormal triglyceride accumulation. Although it is established that PNPLA3 has both triacylglycerol lipase and acylglycerol O-acyltransferase activities, is still unknown whether the gene has any additional role in the modulation of the human liver metabolome. To...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24763554
DOI: 10.1152/ajpgi.00335.2013
PMCID: PMC4080161

Genes

PNPLA3

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Metabolic profiling reveals that PNPLA3 induces widespread effects on metabolism beyond triacylglycerol remodeling in Huh-7 hepatoma cells.PMID 24763554Read ↗

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