Article
Genetic polymorphism of cytochrome P450 4F2, vitamin E level and histological response in adults and children with nonalcoholic fatty liver disease who participated in PIVENS and TONIC clinical trials.
PloS one - 1 Jan 2014
Athinarayanan Shaminie, Wei Rongrong, Zhang Min, Bai Shaochun, Traber Maret G, Yates Katherine, Cummings Oscar W, Molleston Jean, Liu Wanqing, Chalasani Naga
Abstract excerpt
Vitamin E improved liver histology in children and adults with NAFLD who participated in TONIC and PIVENS clinical trials, but with significant inter-individual variability in its efficacy. Cytochrome P450 4F2 (CYP4F2) is the major enzyme metabolizing Vit E, with two common genetic variants (V433M, rs2108622 and W12G, rs3093105) found to alter its activity. We investigated the relationship between CYP4F2...
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