A conserved suppressor mutation in a tryptophan auxotroph results in dysregulation of Pseudomonas quinolone signal synthesis.

Abstract excerpt

Pseudomonas aeruginosa is a common nosocomial pathogen that relies on three cell-to-cell signals to regulate multiple virulence factors. The Pseudomonas quinolone signal (PQS; 2-heptyl-3-hydroxy-4-quinolone) is one of these signals, and it is known to be important for P. aeruginosa pathogenesis. PQS is synthesized in a multistep reaction that condenses anthranilate and a fatty acid. In P. aeruginosa, anthranilate...

Topics

• Chorismic Acid
• Gene Expression Regulation, Bacterial
• Molecular Structure
• Mutation
• Polymerase Chain Reaction
• Pseudomonas aeruginosa
• Quinolones
• Tryptophan
• ortho-Aminobenzoates