Article
The muscle ankyrin repeat proteins CARP, Ankrd2, and DARP are not essential for normal cardiac development and function at basal conditions and in response to pressure overload.
PloS one - 1 Jan 2014
Bang Marie-Louise, Gu Yusu, Dalton Nancy D, Peterson Kirk L, Chien Kenneth R, Chen Ju
Abstract excerpt
Ankrd1/CARP, Ankrd2/Arpp, and Ankrd23/DARP belong to a family of stress inducible ankyrin repeat proteins expressed in striated muscle (MARPs). The MARPs are homologous in structure and localized in the nucleus where they negatively regulate gene expression as well as in the sarcomeric I-band, where they are thought to be involved in mechanosensing. Together with their strong induction during cardiac disease and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.