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Article

The enigmatic role of the ankyrin repeat domain 1 gene in heart development and disease

1 Jan 2008

Abstract excerpt

It has been proposed that the ankyrin repeat domain 1 (ANKRD1) factor (also known as CARP) plays a critical role in transcriptional regulation, myofibrillar assembly and stretch sensing during heart development and cardiac insults. ANKRD1/CARP has also been reported to negatively regulate cardiac gene expression in cell-based promoter-reporter assays. Consequently, rapid up-regulation of the ankrd1 gene in...

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Identifiers

PMID: 18956313
DOI: 10.1387/ijdb.082655am

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