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Article

Lossy compression of quality scores in genomic data.

Bioinformatics (Oxford, England) - 1 Aug 2014

Cánovas Rodrigo, Moffat Alistair, Turpin Andrew

Abstract excerpt

MOTIVATION: Next-generation sequencing technologies are revolutionizing medicine. Data from sequencing technologies are typically represented as a string of bases, an associated sequence of per-base quality scores and other metadata, and in aggregate can require a large amount of space. The quality scores show how accurate the bases are with respect to the sequencing process, that is, how confident the sequencer...

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PMID: 24728856
DOI: 10.1093/bioinformatics/btu183

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