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GSC: efficient lossless compression of VCF files with fast query.

GigaScience - 2 Jan 2024

Luo Xiaolong, Chen Yuxin, Liu Ling, Ding Lulu, Li Yuxiang, Li Shengkang, Zhang Yong, Zhu Zexuan

Abstract excerpt

BACKGROUND: With the rise of large-scale genome sequencing projects, genotyping of thousands of samples has produced immense variant call format (VCF) files. It is becoming increasingly challenging to store, transfer, and analyze these voluminous files. Compression methods have been used to tackle these issues, aiming for both high compression ratio and fast random access. However, existing methods have not yet...

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PMID: 39028587
DOI: 10.1093/gigascience/giae046
PMCID: PMC11258903

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