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Article

Evolution of the F-box gene family in Euarchontoglires: gene number variation and selection patterns.

PloS one - 1 Jan 2014

Wang Ailan, Fu Mingchuan, Jiang Xiaoqian, Mao Yuanhui, Li Xiangchen, Tao Shiheng

Abstract excerpt

F-box proteins are substrate adaptors used by the SKP1-CUL1-F-box protein (SCF) complex, a type of E3 ubiquitin ligase complex in the ubiquitin proteasome system (UPS). SCF-mediated ubiquitylation regulates proteolysis of hundreds of cellular proteins involved in key signaling and disease systems. However, our knowledge of the evolution of the F-box gene family in Euarchontoglires is limited. In the present...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24727786
DOI: 10.1371/journal.pone.0094899
PMCID: PMC3984280

Genes

CUL1
SKP1

Provenance

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