Article
Identification of regions critical for the integrity of the TSC1-TSC2-TBC1D7 complex.
PloS one - 1 Jan 2014
Santiago Lima Arthur Jorge, Hoogeveen-Westerveld Marianne, Nakashima Akio, Maat-Kievit Anneke, van den Ouweland Ans, Halley Dicky, Kikkawa Ushio, Nellist Mark
Abstract excerpt
The TSC1-TSC2-TBC1D7 complex is an important negative regulator of the mechanistic target of rapamycin complex 1 that controls cell growth in response to environmental cues. Inactivating TSC1 and TSC2 mutations cause tuberous sclerosis complex (TSC), an autosomal dominant disorder characterised by the occurrence of benign tumours in various organs and tissues, notably the brain, skin and kidneys. TBC1D7 mutations...
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