Article
Replication protein of tobacco mosaic virus cotranslationally binds the 5' untranslated region of genomic RNA to enable viral replication.
Proceedings of the National Academy of Sciences of the United States of America - 22 Apr 2014
Kawamura-Nagaya Kazue, Ishibashi Kazuhiro, Huang Ying-Ping, Miyashita Shuhei, Ishikawa Masayuki
Abstract excerpt
Genomic RNA of positive-strand RNA viruses replicate via complementary (i.e., negative-strand) RNA in membrane-bound replication complexes. Before replication complex formation, virus-encoded replication proteins specifically recognize genomic RNA molecules and recruit them to sites of replication. Moreover, in many of these viruses, selection of replication templates by the replication proteins occurs...
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