A Y-shaped RNA structure in the 3' untranslated region together with the trans-activator and core promoter of Red clover necrotic mosaic virus RNA2 is required for its negative-strand RNA synthesis.

doi:10.1016/j.virol.2010.05.022

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Article

A Y-shaped RNA structure in the 3' untranslated region together with the trans-activator and core promoter of Red clover necrotic mosaic virus RNA2 is required for its negative-strand RNA synthesis.

Virology - 15 Sept 2010

An Mengnan, Iwakawa Hiro-oki, Mine Akira, Kaido Masanori, Mise Kazuyuki, Okuno Tetsuro

Abstract excerpt

Red clover necrotic mosaic virus (RCNMV) is a positive-strand RNA virus with a bipartite genome. RNA1 encodes N-terminally overlapping replication proteins, p27 and p88. RNA2 is replicated efficiently by the replication proteins supplied in trans, whereas RNA1 needs p88 preferentially in cis for its replication. cis-Acting elements required for RNA2 replication have been mapped to the 3' terminal stem-loop...

Topics

3' Untranslated Regions
Gene Expression Regulation, Viral
Mutation
Nucleic Acid Conformation
Promoter Regions, Genetic
RNA, Viral
Tombusviridae
Trans-Activators
Viral Proteins

Source

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Identifiers

PMID: 20561661
DOI: 10.1016/j.virol.2010.05.022

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