Article
[Association of interleukin-6 and interleukin-18 gene polymorphism with rheumatoid arthritis in Guangdong Han population].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University - 1 Nov 2007
Huang Xian-zhang, Zhuang Jun-hua, Ren Yan-ge, Zhou Luo-jing, Zhou Qiang
Abstract excerpt
OBJECTIVE: To investigate the single-nucleotide polymorphisms (SNPs) at positions -572 and -174 in the promoter region of interleukin-6 (IL-6) gene and at -607 and -137 in the promoter region of interleukin-18 (IL-18) gene for their association with rheumatoid arthritis (RA) in the Chinese Han population in Guangdong Province. METHODS: SNPs of IL-6 and IL-18 genes were detected in 120 patients with RA and 168...
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