Article
VCL-ALK renal cell carcinoma in children with sickle-cell trait: the eighth sickle-cell nephropathy?
The American journal of surgical pathology - 1 Jun 2014
Smith Nathaniel E, Deyrup Andrea T, Mariño-Enriquez Adrian, Fletcher Jonathan A, Bridge Julia A, Illei Peter B, Netto George J, Argani Pedram
Abstract excerpt
We report the third case of a renal cell carcinoma bearing a fusion of the vinculin (VCL) and anaplastic lymphoma kinase (ALK) genes. Like the 2 other reported cases, this neoplasm occurred in a young patient (6 y old) with sickle-cell trait and demonstrated distinctive morphologic features including medullary epicenter, discohesive polygonal or spindle-shaped cells with prominent cytoplasmic vacuoles, and...
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