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Article

Gene targeting techniques for Huntington's disease.

Ageing research reviews - 1 Sept 2021

Fields Eric, Vaughan Erik, Tripu Deepika, Lim Isabelle, Shrout Katherine, Conway Jessica, Salib Nicole, Lee Yubin, Dhamsania Akash, Jacobsen Michael, Woo Ashley, Xue Huijing, Cao Kan

Abstract excerpt

Huntington's disease (HD) is an autosomal neurodegenerative disorder caused by extended trinucleotide CAG repetition in the HTT gene. Wild-type huntingtin protein (HTT) is essential, involved in a variety of crucial cellular functions such as vesicle transportation, cell division, transcription regulation, autophagy, and tissue maintenance. The mutant HTT (mHTT) proteins in the body interfere with HTT's normal...

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Identifiers

PMID: 34098113
DOI: 10.1016/j.arr.2021.101385
PMCID: PMC8373677

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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