Article
Impaired metabolic reactivity to oxidative stress in early psychosis patients.
Schizophrenia bulletin - 1 Sept 2014
Fournier Margot, Ferrari Carina, Baumann Philipp S, Polari Andrea, Monin Aline, Bellier-Teichmann Tanja, Wulff Jacob, Pappan Kirk L, Cuenod Michel, Conus Philippe, Do Kim Q
Abstract excerpt
Because increasing evidence point to the convergence of environmental and genetic risk factors to drive redox dysregulation in schizophrenia, we aim to clarify whether the metabolic anomalies associated with early psychosis reflect an adaptation to oxidative stress. Metabolomic profiling was performed to characterize the response to oxidative stress in fibroblasts from control individuals (n = 20) and early...
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