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Purine nucleoside phosphorylase activity decline is linked to the decay of the trimeric form of the enzyme.

Archives of biochemistry and biophysics - 1 May 2014

Wielgus-Kutrowska Beata, Modrak-Wójcik Anna, Dyzma Alicja, Breer Katarzyna, Zolkiewski Michal, Bzowska Agnieszka

Abstract excerpt

Homotrimeric mammalian purine nucleoside phosphorylase (PNP) plays a key role in the nucleoside and nucleotide metabolic salvage pathway. Each monomer in the active PNP trimer is composed of a central β-sheet flanked by several α-helices. We investigated the stability of calf PNP using analytical ultracentrifugation, differential scanning calorimetry, circular dichroism, and UV absorption spectroscopy. The...

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PMID: 24686197
DOI: 10.1016/j.abb.2014.03.009

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PNP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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