Purine nucleoside phosphorylase activity decline is linked to the decay of the trimeric form of the enzyme.

doi:10.1016/j.abb.2014.03.009

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Article

Purine nucleoside phosphorylase activity decline is linked to the decay of the trimeric form of the enzyme.

Archives of biochemistry and biophysics - 1 May 2014

Wielgus-Kutrowska Beata, Modrak-Wójcik Anna, Dyzma Alicja, Breer Katarzyna, Zolkiewski Michal, Bzowska Agnieszka

Abstract excerpt

Homotrimeric mammalian purine nucleoside phosphorylase (PNP) plays a key role in the nucleoside and nucleotide metabolic salvage pathway. Each monomer in the active PNP trimer is composed of a central β-sheet flanked by several α-helices. We investigated the stability of calf PNP using analytical ultracentrifugation, differential scanning calorimetry, circular dichroism, and UV absorption spectroscopy. The...

Topics

Amino Acid Sequence
Animals
Cattle
Models, Molecular
Molecular Sequence Data
Mutation
Protein Denaturation
Protein Multimerization
Protein Structure, Quaternary
Purine-Nucleoside Phosphorylase

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PMID: 24686197
DOI: 10.1016/j.abb.2014.03.009

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