Article
A multi-trait, meta-analysis for detecting pleiotropic polymorphisms for stature, fatness and reproduction in beef cattle.
PLoS genetics - 1 Mar 2014
Bolormaa Sunduimijid, Pryce Jennie E, Reverter Antonio, Zhang Yuandan, Barendse William, Kemper Kathryn, Tier Bruce, Savin Keith, Hayes Ben J, Goddard Michael E
Abstract excerpt
Polymorphisms that affect complex traits or quantitative trait loci (QTL) often affect multiple traits. We describe two novel methods (1) for finding single nucleotide polymorphisms (SNPs) significantly associated with one or more traits using a multi-trait, meta-analysis, and (2) for distinguishing between a single pleiotropic QTL and multiple linked QTL. The meta-analysis uses the effect of each SNP on each of...
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