Article
Age-dependent changes of nuclear morphology are uncoupled from longevity in Caenorhabditis elegans IGF/insulin receptor daf-2 mutants.
Biogerontology - 1 Jun 2014
Pérez-Jiménez Mercedes M, Rodríguez-Palero María Jesús, Ródenas Eduardo, Askjaer Peter, Muñoz Manuel J
Abstract excerpt
Nuclear envelope (NE) architecture and aging have been associated since the discovery that certain human progeria diseases are due to perturbations in processing of lamin A protein, generating alterations in NE morphology. However, whether changes in the NE are a causal effect of normal and premature aging is still controversial. Caenorhabditis elegans is a model organism where observations supporting both,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.