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Article

Tumors perturbing extracellular matrix biosynthesis. The case of von Recklinghausen's disease.

Pathologie-biologie - 1 Apr 2014

Robert L

Abstract excerpt

This is a short review of neurofibromatosis-1 or von Recklinghausen's disease, due to a loss of function mutation of the gene neurofibromin-1, which normally inhibits the Ras MAPK-pathways. Among its symptoms, the strong oversynthesis of several collagen types designates this disease as producing a deregulation of extracellular matrix biosynthesis involved in tumor formation. Up to about 40% of the skin tumors...

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Identifiers

PMID: 24650525
DOI: 10.1016/j.patbio.2014.02.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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