Article
Familial hemiplegic migraine due to L263V SCN1A mutation: discordance for epilepsy between two kindreds from Douro Valley.
Cephalalgia : an international journal of headache - 1 Oct 2014
Barros José, Ferreira Augusto, Brandão Ana F, Lemos Carolina, Correia Fernando, Damásio Joana, Tuna Assunção, Sequeiros Jorge, Coutinho Paula, Alonso Isabel, Pereira-Monteiro José
Abstract excerpt
BACKGROUND: SCN1A is the most relevant gene in epilepsy. Only seven SCN1A mutations have been identified in 10 familial hemiplegic migraine (FHM) kindreds worldwide. CASES AND KINDREDS: In 2009, we presented a kindred with FHM due to the L263V SCN1A mutation. In the current study, we report a novel FHM3 kindred from the same village. The first family exhibited the co-occurrence of FHM and epilepsy. No case of...
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