Article
GATA5 loss-of-function mutations associated with congenital bicuspid aortic valve.
International journal of molecular medicine - 1 May 2014
Shi Lin-Mei, Tao Ju-Wei, Qiu Xing-Biao, Wang Juan, Yuan Fang, Xu Lei, Liu Hua, Li Ruo-Gu, Xu Ying-Jia, Wang Qian, Zheng Hong-Zhen, Li Xin, Wang Xiao-Zhou, Zhang Min, Qu Xin-Kai, Yang Yi-Qing
Abstract excerpt
Bicuspid aortic valve (BAV) is the most common form of congenital cardiovascular defect in humans worldwide and is responsible for substantial morbidity and mortality. Accumulating evidence has demonstated that genetic risk factors are involved in the pathogenesis of BAV. However, BAV is genetically heterogeneous and the genetic basis underlying BAV in a large number of patients remains unknown. In the present...
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