Integrated next-generation sequencing and avatar mouse models for personalized cancer treatment.

doi:10.1158/1078-0432.CCR-13-3047

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Article

Integrated next-generation sequencing and avatar mouse models for personalized cancer treatment.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2014

Garralda Elena, Paz Keren, López-Casas Pedro P, Jones Siân, Katz Amanda, Kann Lisa M, López-Rios Fernando, Sarno Francesca, Al-Shahrour Fátima, Vasquez David, Bruckheimer Elizabeth, Angiuoli Samuel V, Calles Antonio, Diaz Luis A, Velculescu Victor E, Valencia Alfonso, Sidransky David, Hidalgo Manuel

Abstract excerpt

BACKGROUND: Current technology permits an unbiased massive analysis of somatic genetic alterations from tumor DNA as well as the generation of individualized mouse xenografts (Avatar models). This work aimed to evaluate our experience integrating these two strategies to personalize the treatment of patients with cancer. METHODS: We performed whole-exome sequencing analysis of 25 patients with advanced solid...

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PMID: 24634382
DOI: 10.1158/1078-0432.CCR-13-3047
PMCID: PMC4322867

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