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Article

Prediction of steps in the evolution of variola virus host range.

PloS one - 1 Jan 2014

Smithson Chad, Purdy Alex, Verster Adrian J, Upton Chris

Abstract excerpt

Variola virus, the agent of smallpox, has a severely restricted host range (humans) but a devastatingly high mortality rate. Although smallpox has been eradicated by a World Health Organization vaccination program, knowledge of the evolutionary processes by which human super-pathogens such as variola virus arise is important. By analyzing the evolution of variola and other closely related poxviruses at the level...

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Identifiers

PMID: 24626337
DOI: 10.1371/journal.pone.0091520
PMCID: PMC3953476

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