Article
Genome sequence diversity and clues to the evolution of variola (smallpox) virus.
Science (New York, N.Y.) - 11 Aug 2006
Esposito Joseph J, Sammons Scott A, Frace A Michael, Osborne John D, Olsen-Rasmussen Melissa, Zhang Ming, Govil Dhwani, Damon Inger K, Kline Richard, Laker Miriam, Li Yu, Smith Geoffrey L, Meyer Hermann, Leduc James W, Wohlhueter Robert M
Abstract excerpt
Comparative genomics of 45 epidemiologically varied variola virus isolates from the past 30 years of the smallpox era indicate low sequence diversity, suggesting that there is probably little difference in the isolates' functional gene content. Phylogenetic clustering inferred three clades coincident with their geographical origin and case-fatality rate; the latter implicated putative proteins that mediate viral...
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