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Article

Epistasis between polymorphisms in PCSK1 and DBH is associated with premature ovarian failure.

Menopause (New York, N.Y.) - 1 Nov 2014

Pyun Jung-A, Kim Sunshin, Cha Dong Hyun, Kwack KyuBum

Abstract excerpt

OBJECTIVE: This study examined whether epistasis between single nucleotide polymorphisms (SNPs) within proprotein convertase subtilisin/kexin type 1 (PCSK1) and dopamine β-hydroxylase (DBH) genes is associated with premature ovarian failure (POF). METHODS: One hundred twenty women with POF and 222 female controls were recruited for this study. To genotype SNPs within PCSK1 and DBH, we used a GoldenGate assay with...

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Source

Identifiers

PMID: 24618767
DOI: 10.1097/GME.0000000000000226

Genes

DBH
PCSK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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