Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Common variants in DGKK are strongly associated with risk of hypospadias.

Nature genetics - 1 Jan 2011

van der Zanden Loes F M, van Rooij Iris A L M, Feitz Wout F J, Knight Jo, Donders A Rogier T, Renkema Kirsten Y, Bongers Ernie M H F, Vermeulen Sita H H M, Kiemeney Lambertus A L M, Veltman Joris A, Arias-Vásquez Alejandro, Zhang Xufeng, Markljung Ellen, Qiao Liang, Baskin Laurence S, Nordenskjöld Agneta, Roeleveld Nel, Franke Barbara, Knoers Nine V A M

Abstract excerpt

Hypospadias is a common congenital malformation of the male external genitalia. We performed a genome-wide association study using pooled DNA from 436 individuals with hypospadias (cases) and 494 controls of European descent and selected the highest ranked SNPs for individual genotyping in the di...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diacylglycerol Kinase
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Genome-Wide Association Study

Share to Hypospadias

Share to Odds Ratio

Share to Polymorphism, Single Nucleotide

Share to Risk Factors

Source

Identifiers

PMID: 21113153
DOI: 10.1038/ng.721

Genes

DGKK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21113153-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Common variants in DGKK are strongly associated with risk of hypospadias.PMID 21113153Read ↗

Further Evidence of the Association of the Diacylglycerol Kinase Kappa (DGKK) Gene With Hypospadias.Semantic proximity Read ↗

Diacylglycerol kinase K variants impact hypospadias in a California study population.Semantic proximity Read ↗

Diacylglycerol kinase κ (DGKK) variants and hypospadias in Han Chinese: association and meta-analysis.Semantic proximity Read ↗

Association between diacylglycerol kinase kappa variants and hypospadias susceptibility in a Han Chinese population.Semantic proximity Read ↗

[Single nucleotide polymorphisms of the DGKK gene and hypospadias in Chinese children].Semantic proximity Read ↗

Novel genetic associations and range of phenotypes in Deciphering Developmental Disorders (DDD) study participants with hypospadiasSemantic proximity Read ↗

Genome-wide association analyses identify variants in developmental genes associated with hypospadias.Semantic proximity Read ↗

Fine mapping analysis confirms and strengthens linkage of four chromosomal regions in familial hypospadias.Semantic proximity Read ↗

Association between CACNA1D polymorphisms and hypospadias in a southern Chinese population.Semantic proximity Read ↗

Identifying infrequent genetic changes in monozygotic twins afflicted with hypospadias via targeted panel sequencing.Semantic proximity Read ↗

Genetic insights into hypospadias in the Taiwanese population: A whole-exome sequencing study in a single center.Semantic proximity Read ↗

Phenotype expansion of variants affecting p38 MAPK signaling in hypospadias patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.