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Article

A gradient-boosting approach for filtering de novo mutations in parent-offspring trios.

Bioinformatics (Oxford, England) - 1 Jul 2014

Liu Yongzhuang, Li Bingshan, Tan Renjie, Zhu Xiaolin, Wang Yadong

Abstract excerpt

MOTIVATION: Whole-genome and -exome sequencing on parent-offspring trios is a powerful approach to identifying disease-associated genes by detecting de novo mutations in patients. Accurate detection of de novo mutations from sequencing data is a critical step in trio-based genetic studies. Existi...

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PMID: 24618463
DOI: 10.1093/bioinformatics/btu141
PMCID: PMC4071207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24618463-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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