Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence of TRK-Fused Gene (TFG1) function in the ubiquitin-proteasome system.

Neurobiology of disease - 1 Jun 2014

Yagi Takuya, Ito Daisuke, Suzuki Norihiro

Abstract excerpt

A heterozygous mutation in the TRK-Fused Gene (TFG1) has recently been identified in hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P). TFG1 protein is reportedly localized at endoplasmic reticulum (ER) exit sites and modulates ER export, but the mechanism of its action in neurodegeneration remains unclear. To clarify the molecular pathogenesis of HMSN-P, we examined the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endoplasmic Reticulum
Share to Endoplasmic Reticulum Stress
Share to Fluorescent Antibody Technique

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knockdown Techniques

Share to Proteasome Endopeptidase Complex

Share to Proteolysis

Share to Ubiquitin

Share to Ubiquitination

Source

Identifiers

PMID: 24613659
DOI: 10.1016/j.nbd.2014.02.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence of TRK-Fused Gene (TFG1) function in the ubiquitin-proteasome system.PMID 24613659Read ↗

TFG-Related Neurologic Disorders: New Insights Into Relationships Between Endoplasmic Reticulum and Neurodegeneration.Semantic proximity Read ↗

The TRK-fused gene is mutated in hereditary motor and sensory neuropathy with proximal dominant involvement.Semantic proximity Read ↗

Proteasome impairment in neural cells derived from HMSN-P patient iPSCs.Semantic proximity Read ↗

Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure.Semantic proximity Read ↗

Proximal dominant hereditary motor and sensory neuropathy with proximal dominance association with mutation in the TRK-fused gene.Semantic proximity Read ↗

A novel TFG mutation causes Charcot-Marie-Tooth disease type 2 and impairs TFG function.Semantic proximity Read ↗

Novel TFG mutation causes autosomal-dominant spastic paraplegia and defects in autophagy.Semantic proximity Read ↗

[Hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P) is caused by a mutation in TFG].Semantic proximity Read ↗

Pathogenic TFG Mutations Underlying Hereditary Spastic Paraplegia Impair Secretory Protein Trafficking and Axon Fasciculation.Semantic proximity Read ↗

Multiple roles for TFG ring complexes in neuronal cargo traffickingSemantic proximity Read ↗

A novel degron-mediated degradation of the RTG pathway regulator, Mks1p, by SCFGrr1.Semantic proximity Read ↗

Fukutin-related protein localizes to the Golgi apparatus and mutations lead to mislocalization in muscle in vivo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.