Article
Gene conversion violates the stepwise mutation model for microsatellites in y-chromosomal palindromic repeats.
Human mutation - 1 May 2014
Balaresque Patricia, King Turi E, Parkin Emma J, Heyer Evelyne, Carvalho-Silva Denise, Kraaijenbrink Thirsa, de Knijff Peter, Tyler-Smith Chris, Jobling Mark A
Abstract excerpt
The male-specific region of the human Y chromosome (MSY) contains eight large inverted repeats (palindromes), in which high-sequence similarity between repeat arms is maintained by gene conversion. These palindromes also harbor microsatellites, considered to evolve via a stepwise mutation model (SMM). Here, we ask whether gene conversion between palindrome microsatellites contributes to their mutational dynamics....
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