Article
[Lamin A/C mutations change differentiation potential of mesenchymal stem cells].
Tsitologiia - 1 Jan 2013
Malashicheva A B, Zabirnik A S, Smolina N A, Omel'chenko E A, Dmitrieva R I, Kostareva A A
Abstract excerpt
Mutations in lamin A/C gene (LMNA) lead to development of severe disorders--laminopathies. Unlike most other types of intermediate filaments, where the pathological effect of mutations is tightly linked to alteration of mechanical and integrative functions, the detailed mechanism of lamin mutations is still unclear and possibly involves the alteration of nuclear signaling and transcriptional processes. Since the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.