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Article

Death receptor (DR4) haplotypes are associated with increased susceptibility of gallbladder carcinoma in north Indian population.

PloS one - 1 Jan 2014

Rai Rajani, Sharma Kiran L, Sharma Surbhi, Misra Sanjeev, Kumar Ashok, Mittal Balraj

Abstract excerpt

BACKGROUND AND AIM: Defective apoptosis is a hallmark of cancer development and progression. Death receptors (DR4, FAS) and their ligands (TRAIL, FASL) are thought to mediate the major extrinsic apoptotic pathway in the cell. SNPs in these genes may lead to defective apoptosis. Hence, the present study aimed to investigate the association of functional SNPs of DR4 (rs20575, rs20576 and rs6557634), FAS (rs2234767)...

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Source

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Identifiers

PMID: 24587306
DOI: 10.1371/journal.pone.0090264
PMCID: PMC3938657

Genes

FAS

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