Article
Evidence for an epistatic effect between TP53 R72P and MDM2 T309G SNPs in HIV infection: a cross-sectional study in women from South Brazil.
PloS one - 1 Jan 2014
Hartwig Fernando Pires, Entiauspe Ludmila Gonçalves, Nunes Emily Montosa, Rodrigues Fernanda Martins, Collares Tiago, Seixas Fabiana Kömmling, da Silveira Mariângela Freitas
Abstract excerpt
OBJECTIVE: To investigate the associations of TP53 R72P and MDM2 T309G SNPs with HPV infection status, HPV oncogenic risk and HIV infection status. DESIGN: Cross-sectional study combining two groups (150 HIV-negative and 100 HIV-positive) of women. METHODS: Data was collected using a closed questionnaire. DNA was extracted from cervical samples. HPV infection status was determined by nested-PCR, and HPV oncogenic...
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