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Article

Prospects for neuroprotective therapies in prodromal Huntington's disease

26 Feb 2014

Abstract excerpt

Huntington's disease (HD) is a prototypical dominantly inherited neurodegenerative disorder characterized by progressive cognitive deterioration, psychiatric disturbances, and a movement disorder. The genetic cause of the illness is a CAG repeat expansion in the huntingtin gene, which leads to a polyglutamine expansion in the huntingtin protein. The exact mechanism by which mutant huntingtin causes HD is unknown,...

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PMID: 24573776
DOI: 10.1002/mds.25835

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