Article
Emergence of genetically variant Hepatitis C virus population in response to increased antiviral drug pressure, Pakistan.
Virus genes - 1 Jun 2014
Ali Muhammad, Rehman Irshad Ur, Idrees Muhammad
Abstract excerpt
Mutations in NS5B gene of Hepatitis C virus (HCV) have been reported in patients undergoing antiviral therapy. In the present study, we report emerging clade of HCV-3a in patients administered with IFN plus ribavirin therapy for 24 weeks and having low viral loads (<250 IU/mL). Mutations D/N244E, K304R, N/K307G, Q/T329V, and A338V were found associated with these emerging strains. This distinct HCV could be...
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