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Article

Pre-existing resistance associated polymorphisms to NS3 protease inhibitors in treatment naïve HCV positive Pakistani patients.

PloS one - 1 Jan 2020

Khan Hafeez Ullah, Khan Sanaullah, Shah Muhammad Akbar, Attaullah Sobia, Malik Muhammad Arshad

Abstract excerpt

Chronic Hepatitis C Virus (HCV) infection is still a major health issue especially in endemic areas where fewer direct-acting virals (DAAs) are treatment options. Some HCV variants are associated with resistance and it reduces DAAs success where pre-existing variants prevail. In this study, we investigated resistance-associated polymorphisms (RAPs) in the HCV NS3 region from DAAs naïve Pakistani patients. 277...

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Share to Antiviral Agents
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hepatitis C, Chronic

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Share to Polymorphism, Genetic

Share to Sequence Analysis, DNA

Share to Viral Nonstructural Proteins

Source

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Identifiers

PMID: 32275694
DOI: 10.1371/journal.pone.0231480
PMCID: PMC7147739

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