Article
Estimating risk of C. difficile transmission from PCR positive but cytotoxin negative cases.
PloS one - 1 Jan 2014
Kamboj Mini, Babady N Esther, Marsh Jane W, Schlackman Jessica L, Son Crystal, Sun Janet, Eagan Janet, Tang Yi-Wei, Sepkowitz Kent
Abstract excerpt
BACKGROUND: The use of molecular methods to diagnose Clostridium difficile infection (CDI) has improved diagnostic yield compared to conventional methods. However, PCR testing can detect colonization and has introduced several practical challenges pertaining to need for treatment and isolation of cases. METHODS: For all new cases detected by real-time PCR, concurrent cytotoxin assay was performed and genetic...
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