Lack of association between the CHL1 gene and adolescent idiopathic scoliosis susceptibility in Han Chinese: a case-control study.

doi:10.1186/1471-2474-15-38

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Article

Lack of association between the CHL1 gene and adolescent idiopathic scoliosis susceptibility in Han Chinese: a case-control study.

BMC musculoskeletal disorders - 10 Feb 2014

Qiu Xu-Sheng, Lv Feng, Zhu Ze-Zhang, Qian Bang-Ping, Wang Bin, Yu Yang, Qiu Yong

Abstract excerpt

BACKGROUND: A previous genome-wide association study (GWAS) suggested a strong association between the single nucleotide polymorphism (SNP) rs10510181 in the proximity of the gene encoding a cell adhesion molecule with homology to L1CAM (CHL1) and adolescent idiopathic scoliosis (AIS) in Caucasians. To clarify the role of CHL1 in the etiopathogenesis of AIS, we performed a case-control replication study in a Han...

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PMID: 24512353
DOI: 10.1186/1471-2474-15-38
PMCID: PMC3925962

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CHL1

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