Article
Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission.
Nature medicine - 1 Mar 2014
Balazs Alejandro B, Ouyang Yong, Hong Christin M, Chen Joyce, Nguyen Steven M, Rao Dinesh S, An Dong Sung, Baltimore David
Abstract excerpt
The vast majority of new HIV infections result from relatively inefficient transmission of the virus across mucosal surfaces during sexual intercourse. A consequence of this inefficiency is that small numbers of transmitted founder viruses initiate most heterosexual infections. This natural bottleneck to transmission has stimulated efforts to develop interventions that are aimed at blocking this step of the...
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