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Article

Low-dose 6-bromoindirubin-3'-oxime induces partial dedifferentiation of endothelial cells to promote increased neovascularization.

Stem cells (Dayton, Ohio) - 1 Jun 2014

Kohler Erin E, Baruah Jugajyoti, Urao Norifumi, Ushio-Fukai Masuko, Fukai Tohru, Chatterjee Ishita, Wary Kishore K

Abstract excerpt

Endothelial cell (EC) dedifferentiation in relation to neovascularization is a poorly understood process. In this report, we addressed the role of Wnt signaling in the mechanisms of neovascularization in adult tissues. Here, we show that a low-dose of 6-bromoindirubin-3'-oxime (BIO), a competitive inhibitor of glycogen synthase kinase-3β, induced the stabilization of β-catenin and its subsequent direct...

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Identifiers

PMID: 24496925
DOI: 10.1002/stem.1658
PMCID: PMC4037358

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NANOG
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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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