Article
Dovitinib synergizes with oxaliplatin in suppressing cell proliferation and inducing apoptosis in colorectal cancer cells regardless of RAS-RAF mutation status.
Molecular cancer - 4 Feb 2014
Gaur Shikha, Chen Linling, Ann Vincent, Lin Wei-Chen, Wang Yafan, Chang Vincent H S, Hsu Nan Yong, Shia Her-Shuyong, Yen Yun
Abstract excerpt
BACKGROUND: Cancer is the result of a multistep process of genomic alterations, including mutations in key regulatory proteins that result in loss of balanced gene expression and subsequent malignant transformation. Throughout the various stages of colorectal carcinoma (CRC), complex genetic alterations occur, of which over-expression of growth factors, such as vascular endothelial growth factor, fibroblast...
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