Article
MiR-361-5p acts as a tumor suppressor in prostate cancer by targeting signal transducer and activator of transcription-6(STAT6).
Biochemical and biophysical research communications - 28 Feb 2014
Liu Dachuang, Tao Tao, Xu Bin, Chen Shuqiu, Liu Chunhui, Zhang Lei, Lu Kai, Huang Yeqing, Jiang Liang, Zhang Xiaowen, Huang Xiaoming, Zhang Lihua, Han Conghui, Chen Ming
Abstract excerpt
Castration-resistant prostate cancer (CRPC), whose pathogenesis is known to be regulated by microRNAs (miRNAs), has a poor prognosis. In our present study, we found that the expression of miR-361-5p in CRPC was lower than in androgen-dependent prostate cancer (ADPC), indicating that miR-361-5p may play an important role in the progression of ADPC to CRPC. The role of miR-361-5p in prostate cancer (PCa) has not...
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