Article
Glucose metabolism transporters and epilepsy: only GLUT1 has an established role.
Epilepsia - 1 Feb 2014
Hildebrand Michael S, Damiano John A, Mullen Saul A, Bellows Susannah T, Oliver Karen L, Dahl Hans-Henrik M, Scheffer Ingrid E, Berkovic Samuel F
Abstract excerpt
The availability of glucose, and its glycolytic product lactate, for cerebral energy metabolism is regulated by specific brain transporters. Inadequate energy delivery leads to neurologic impairment. Haploinsufficiency of the glucose transporter GLUT1 causes a characteristic early onset encephalopathy, and has recently emerged as an important cause of a variety of childhood or later-onset generalized epilepsies...
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