Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

mGlu3 receptor blockade inhibits proliferation and promotes astrocytic phenotype in glioma stem cells.

Cell biology international - 1 Apr 2014

Zhou Kun, Song Yechun, Zhou Wei, Zhang Chunqing, Shu Haifeng, Yang Hui, Wang Bin

Abstract excerpt

We have characterised, using both in vivo and in vitro methods, the effects of the metabotropic glutamate receptor subtype 3 (mGlu3) antagonist (LY341495) and agonist (LY379268) on the proliferation and differentiation of glioma stem cells (GSC). For in vitro studies, a CCK-8 assay was used to de...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AC133 Antigen
Share to Astrocytes
Share to Bridged Bicyclo Compounds, Heterocyclic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epidermal Growth Factor

Share to Fibroblast Growth Factor 2

Share to Neoplastic Stem Cells

Share to Receptors, Metabotropic Glutamate

Share to Transplantation, Heterologous

Source

Identifiers

PMID: 24482010
DOI: 10.1002/cbin.10207

Genes

GSC
CCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24482010-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

mGlu3 receptor blockade inhibits proliferation and promotes astrocytic phenotype in glioma stem cells.PMID 24482010Read ↗

Cross Interaction between M2 Muscarinic Receptor and Notch1/EGFR Pathway in Human Glioblastoma Cancer Stem Cells: Effects on Cell Cycle Progression and SurvivalSemantic proximity Read ↗

Inhibition of Metabotropic Glutamate Receptor III facilitates sensitization to alkylating chemotherapeutics in GlioblastomaSemantic proximity Read ↗

BIX01294, an inhibitor of histone methyltransferase, induces autophagy-dependent differentiation of glioma stem-like cellsSemantic proximity Read ↗

The activation of M2 muscarinic receptor inhibits cell growth and survival in human glioblastoma cancer stem cellsSemantic proximity Read ↗

Bufalin Inhibits Cellular Proliferation and Cancer Stem Cell-Like Phenotypes via Upregulation of MiR-203 in Glioma.Semantic proximity Read ↗

Downregulation of miRNA-146a-5p promotes malignant transformation of mesenchymal stromal/stem cells by glioma stem-like cellsSemantic proximity Read ↗

PI3K/Akt and Stat3 signaling regulated by PTEN control of the cancer stem cell population, proliferation and senescence in a glioblastoma cell lineSemantic proximity Read ↗

Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cellsSemantic proximity Read ↗

Seizures preferentially stimulate proliferation of radial glia-like astrocytes in the adult dentate gyrus: functional and immunocytochemical analysis.Semantic proximity Read ↗

Astrocyte-induced mGluR1 activates human lung cancer brain metastasis via glutamate-dependent stabilization of EGFRSemantic proximity Read ↗

Perampanel attenuates epileptiform phenotype in C6 glioma.Semantic proximity Read ↗

Glycogen synthase kinase 3 inhibition promotes adult hippocampal neurogenesis in vitro and in vivo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.